
In 2005, Liquid Snake along with FOXHOUND members formed a terrorist group called the Sons of Big Boss. The terrorists seized control of Shadow Moses Island and the nuclear equipped Metal Gear REX, taking the DARPA Chief Donald Anderson and ArmsTech President Kenneth Baker as hostages. Liquid then demanded the preserved remains of Big Boss in order to produce a cure for the genetic defects of the Genome Army. Basing himself in the Shadow Moses facility, and supported by FOXHOUND, the Genome Army, and Metal Gear's nuclear capabilities, Liquid intended to recreate Outer Heaven. With these vast resources at his command, Liquid would drag the world into the Third World War, w anting to fulfil Big Boss' dream of a world which always had a place for soldiers.
During the course of Solid Snake's mission to eliminate the nuclear threat, he was confronted by Liquid on several occasions. The entire final act of the Shadow Moses Island incident was a series of battles between Snake and Liquid. First, Liquid piloted Metal Gear REX and attacked Snake, but, with the help of Gray Fox, Snake destroyed Metal Gear. Then, Liquid and Snake battled bare-handed atop the ruins of Metal Gear, attempting to fling each other from the top of the ruined bipedal tank to the ground far below. While it seemed Snake was victorious in this struggle, Liquid, still able to fire a FAMAS one-handed, pursued him as he tried to escape from the impending nuclear strike. Ultimately, Liquid fell victim to the genetically engineered FOXDIE virus, just outside the facility, and died.